"Dodgers 5 - Tigers 4" (27th, Los Angeles)

Shohei Ohtani played as the leadoff and designated hitter in the US Opening Game at home field, and in the seventh inning with the score at 4-3, he hit his second solo home run over the left field fence off third-string right-hander Hanifee. In the third inning, he recorded his first hit, a single to right field, against last season's Cy Young Award winner Skubal in his eighth at-bat. It was his second multi-hit game in the opening three games, and he finished with a batting average of .417 and an OPS of 1.500.

At the post-game press conference, manager Roberts praised Tigers starter Skubal, saying, "He's a tough pitcher. I'd say he's one of the best in the league," and added, "Shohei made a good hit (in the third inning) and hit it sharply." He also commented on the seventh inning home run, saying, "There aren't many batters, even in the majors, who can hit home runs in the opposite direction. He never disappoints."

He also recalled the home opening game he played in after being involved in a crime committed by his former interpreter in the opening game in Korea last year, his first year after the transfer, and said, "He's in a good mental state now, so it's great to see him playing comfortably."